Chances are, I don't know what I'm talknig about, but I don't think you can block Crt+Alt+Del. When you logon to an NT box, there is a little help topic explaining that Ctr+Alt+Del send an interupt command to the machine, which is how they keep passwords safe, or something to that effect.
But, like I said, I'm not speaking from experience.
-bZj