I read at tweak3d that NFTS would be faster especially on large partitions. Is there any bad points if I convert my current FAT32 win2k to NFTS? Do any games or programs have problems with it?

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Celeron 300a@464 on a Abit BH6 Rev 1.01, 192 Pc100, Matrox G400 32 SH,
SBlive Value, Supra Express 56i ISA, all running on Win2k pro with other
odds and ends