fare- not much information there to go on, you know :-) All I can tell you is that palm desktop installs fine on Win2k Final. So:
1. Are you installing with admin priveleges?
2. What build of win2k are you using?
3. Is the problem running the software or installing it? If the problem is installing it then go to the temp dir (under documents and settings\your user name\temp and make sure that directory is cleaned out then try to install again.
4. Download the palm desktop software from 3com (there is a new version anyways) because you install files may be hosed for some reason.
Let me know what happens and try to give a little more detail about your system and what is actually happening.
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Shrink
92% of the things we worry about don't happen - but the other 8% DO!