You should be able to run it without any problems. It's worked just fine for me when I installed it on an XP machine.
Try uninstalling it, reboot, then disable any antivirus or anti-spyware applications before isntalling. If that doesn't help, go into your event viewer and see if there are any messages which could tell you more about the error.
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I swear, troubleshooting is a science: the best discoveries are always on accident...