I reboot after running my win2k system for about 3 days. Now text on websites (which don't specify text style) is in italics, same goes for the playlist in winamp and a couple other apps. I edit appearance in display options and it does not change anything. I scan hd for viruses and find js_gigger but nothing in the description says anything about text being changed to italics. I remove it reboot and text is the same. Scanned again to make sure and no viruses. I did not install anything that I have not installed before during those 3 days I had the OS running.

Never had this kind of problem before...any ideas?

This may not help, but have you tried changing the color scheme in windows? Doing so will also change the default fonts... It's right in the control panel, under display, and appearance. Just for the sake of argument, try a different scheme, and click apply.

Also, any JS_* virus generally just means bad javascript...

Yes, I tried different color schemes and it did not change the italic text.