NAV is a resource HOG. Expect slowdowns of up to 15%. It's a great choice if you need idiot proof software. Zero user intervention is required for updates and it catches most stuff. It also unleashes a MONSTER to assure proper licensing.
McAfee is low impact, also runs seamless upgrades. version 5 is evil.
trend micro is very low impact but can be system intrusive installing crappy bits of firewall software even when the user chooses not to install the full product. registry hacking required to make it play nicely. not for the novice user. on occasion CPU spike to 100 on startup.
NOD is good on demand. there really is
no cause to continuously run AV software if the user has a modicum of common sense. Surfing with an HTML proxy like, oh, say proxomitron

or privoxy will cut out the need entirely. Again common sense will combat email threats as well. though I've mentioned Disruptor OL in another thread,
http://disruptor.de , it's a plugin for Outlook. It has a cool feature called "secure" that converts HTML to text while retaining HTML formatting and layout (bye bye threats).
there are a few sites that rate the effectiveness of engines at spotting threats. My brain hurts now otherwise I could recall two or three.